The Mark Egly Foundation is executing bold, high-impact initiatives designed to accelerate change in how medicine approaches Alpha-1 Antitrypsin Deficiency and inflammatory disease. Each initiative is purposeful, measurable, and urgently needed.
The Challenge: Current standards of care fail to recognize the full scope of conditions affected by Alpha-1 Antitrypsin deficiency and the therapeutic potential of AAT supplementation.
Our Action Plan:
Publishing Mark's Discoveries
Physician Direct Engagement
Professional Society Collaboration
Updated Clinical Guidelines
Insurance Coverage Expansion
Medical Education Integration
Comprehensive Standard of Care
Measurable Success Indicators:
The Opportunity: Mark's discoveries demonstrate that demand for Alpha-1 Antitrypsin far exceeds what human plasma donation can supply. Alternative production is not just desirable—it's essential.
Historical Context: Previous attempts at plant and animal-based AAT production showed promise but were abandoned when the market seemed limited to traditional AATD patients. Mark's work reveals the true market potential.
Our Action Plan:
Demonstrating Market Potential
Technology Revival and Advancement
Building Public-Private Partnerships
Plant-Based AAT
Animal-Based AAT
Cellular Production
Gene Therapy as Production
Research Grants
Industry Incentives
Expected Timeline:
The Reality: Most physicians receive minimal or no education about AATD, and virtually none learn about AAT's broader therapeutic applications.
Our Vision: Every medical professional should understand AATD, recognize when to test, and know how AAT therapy can benefit their patients.
Multi-Level Education Strategy:
Pre-Clinical Years
Clinical Years
Deliverables:
Specialty-Specific Content
Teaching Methods:
Live Events
Online Learning
Practice Tools
Hospital Systems
Community Health Centers
Academic Medical Centers
Metrics:
Goal: Every physician trained by 2030, with measurable improvements in patient outcomes.
The Need: Public awareness is critically low. Most people have never heard of AATD, and even those affected often go undiagnosed for years.
Target Audiences:
Mass Media Campaigns
Digital Presence
Community Outreach
High-Priority Groups
Targeted Messaging
Newly Diagnosed
Living with AATD
Family Members
Alpha-1 Awareness Month (November)
Year-Round Initiatives
Expected Impact:
Philosophy: We can't wait for perfect solutions. Existing knowledge and treatments can save lives right now.
Immediate Life-Saving Actions:
Targeted Screening
Rapid Diagnosis Pathways
Insurance Authorization Assistance
Financial Assistance Programs
Carrier State Management
At-Risk Family Members
Trial Matching Services
Research Participation
Lives Saved:
Through earlier diagnosis, improved treatment access, and prevention strategies, we aim to prevent 1,000+ premature deaths annually by 2030.
Mark's Vision: These discoveries belong to the world. The medical community should take these findings and soar to heights we can't yet imagine.
How We're Empowering Innovation:
Knowledge Sharing
Patent Strategy
"Uniting Doctors" Platform
Research Resource Sharing
Research Competitions
Young Investigator Programs
New Treatment Protocols
Quality Improvement Projects
Expected Outcomes:
Diagnosis Metrics
Treatment Metrics
Education Metrics
Research Metrics
Impact Metrics
Patients and Families
Healthcare Providers
Researchers
Industry Partners
Donors and Supporters
Mark Egly spent 45 years searching for answers to his family's tragic health history. His discoveries revealed truths that will save millions of lives. But this was never about Mark alone—it was always about the countless families suffering from undiagnosed disease.
Now it's time for the world to take these discoveries and run with them.
The Mark Egly Foundation provides the launchpad—the education, the research support, the advocacy platform, the collaborative networks. We're removing every barrier we can so that medical professionals worldwide can innovate, discover, and heal.
How high can medicine soar with these discoveries?
Let's find out together.
For information about supporting specific initiatives, collaboration opportunities, or getting involved, contact the Mark Egly Foundation.
Every initiative. Every action. Every life saved. This is Mark's legacy becoming reality.